Science
Mechanism of Action
This cationic molecule interacts with negatively charged microbial cell membranes, disrupting integrity and causing intracellular leakage leading to cell death. It acts bacteriostatically at lower doses and bactericidally at higher concentrations, with sustained residual efficacy.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Effective against Gram-positive bacteria at concentrations ≥ 1 μg/mL (0.0001%).
- 02 Demonstrated residual antimicrobial activity on skin, reducing Gram-positive CFUs at >18.75 μg/mL (0.001875%) for up to 24 hours.
- 03 Efficacy against Gram-negative bacteria and fungi requires concentrations from 10 to >73 μg/mL (0.001% to >0.0073%).
Transparency
Dusting Analysis
Chlorhexidine digluconate's efficacy is well-established at specific, low concentrations for antimicrobial action in both medical and cosmetic applications, making dusting unlikely.
The Formula
Formulation
Stability
Aqueous solutions are stable at physiological pH but can decompose if heated above 70 °C.
Conflicts
- Anionic compounds like sodium lauryl sulfate reduce its antimicrobial activity.
- Direct contact with eyes can cause severe and irreversible corneal damage.
Safety
Safety Profile
The CIR Expert Panel considers it safe for cosmetic use up to 0.20%. While non-irritating to normal skin at this level, sensitization was reported at 1.0% in eczema patients.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective broad-spectrum antimicrobial and preservative, valuable for targeted skincare formulations requiring microbial control within established safety limits.
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