Science
Mechanism of Action
It destabilizes bacterial cell membranes by attracting to negatively charged components, leading to leakage of intracellular contents. This dual action results in both bactericidal and bacteriostatic effects, effectively eliminating bacteria.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 The CIR Expert Panel concluded it is safe for cosmetic use up to 0.19% concentration.
- 02 Market surveys show concentrations between 0.01% and 0.15% in various cosmetic product types.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous solutions are most stable between pH 5-8, with activity deteriorating in more acidic conditions and precipitation above pH 8. Avoid prolonged heat above 70 °C and light.
Conflicts
- Anionic agents/surfactants (e.g., carbomer, sodium lauryl sulfate) can lead to inactivation or precipitation.
- Other incompatibilities include sodium hypochlorite, EDTA, saline, and ethanol, which may cause precipitation.
Safety
Safety Profile
The CIR considers it safe up to 0.19% in cosmetics, while the EU allows up to 0.3% as a preservative. The FDA has noted rare serious allergic reactions with related chlorhexidine salts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Chlorhexidine Diacetate is a valuable antimicrobial preservative for cosmetics, though its medium irritancy potential necessitates careful formulation and concentration control.
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