Science
Mechanism of Action
This peptide mimics human EGF, interacting with EGFR on skin cells to stimulate cell growth, proliferation, and differentiation. It accelerates new skin cell production and the synthesis of structural proteins like collagen and elastin.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 General SH-Oligopeptide-1 studies indicate improvements in fine lines, texture, and pore size over three months.
- 02 One study reported a 73% decrease in melasma for subjects using topical EGF twice daily for 8 weeks.
- 03 Another study of 20 subjects showed a 33.5% reduction in inflammatory acne lesions over six weeks.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient may present aesthetic, stability, or other challenges in formulations.
Safety
Safety Profile
The CIR Expert Panel has not reviewed this ingredient. It carries unknown long-term risks, and its preclinical bioactivity for cosmetic use remains unproven. Active EGF is deemed an unauthorized drug by regulatory bodies for medical treatments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While studies suggest benefits for skin texture and tone, the lack of proven preclinical bioactivity for cosmetic use and unknown long-term risks make this ingredient questionable for precision skincare.
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References
Sources