Science
Mechanism of Action
The extract utilizes bioactive sesquiterpenoid dimers, specifically Shizukaol B and D, to downregulate pro-inflammatory enzymes like iNOS and COX-2. By repressing the Wnt/β-catenin signaling pathway, it mitigates the cellular response to stress while simultaneously functioning as a humectant to secure moisture within the stratum corneum.
Research
Clinical Evidence
Medium confidence3%
Key findings
- 01 In vitro analysis confirms Shizukaol D (10-25 μM) significantly inhibits inflammatory mediators including nitric oxide (NO).
- 02 Standardized formulation data indicates efficacy as a soothing humectant at concentrations between 1% and 5%.
Transparency
Dusting Analysis
Because it is a botanical extract often used for 'label claims' in balancing creams, it is frequently included at sub-clinical levels (<1%). For precise therapeutic anti-inflammatory benefits, concentrations should reach at least 1%.
The Formula
Formulation
Stability
Highly stable in standard oil-in-water and water-in-oil emulsions; most effective when delivered in hydro-glycolic bases.
Synergies
- Hyaluronic Acid
- Niacinamide
- Salicylic Acid
Conflicts
- Strong oxidizers
- High pH environments > 8.0
Safety
Safety Profile
Recognized by the EU INCI glossary with a low toxicological risk profile for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical that bridges the gap between hydration and inflammation control, particularly effective for reactive or acne-prone skin.
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