Science
Mechanism of Action
This complex operates via a dual-action pathway: Oligopeptide-91 functions as a neuro-cosmetic agent that targets the SNARE complex to inhibit acetylcholine release, effectively relaxing expression lines with a Botox-like mechanism. Simultaneously, sh-Polypeptide-1 (bFGF) and sh-Polypeptide-11 (aFGF) act as bioactive growth factors that stimulate fibroblast proliferation, accelerating the synthesis of essential collagen, elastin, and hyaluronic acid.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Clinical evaluation of a 0.5% concentration showed a measurable decrease in the depth of periorbital and forehead wrinkles alongside improved skin elasticity after 28 days of consistent use.
- 02 In-vivo analysis of the concentrated 5% raw material demonstrated significant enhancement in Type I collagen production and fibroblast cellular activity compared to untreated controls.
Transparency
Dusting Analysis
Due to the high cost of this recombinant protein complex, it is frequently used at 'label claim' concentrations far below the 0.5% clinical threshold. Formulations containing less than 0.1% may not provide the advertised neuro-relaxing or regenerative benefits.
The Formula
Formulation
Stability
The complex is highly thermolabile; it must be incorporated during the cool-down phase at temperatures not exceeding 40°C to maintain protein folding and biological activity.
Synergies
- Hyaluronic Acid
- Non-proteolytic Peptides
- Antioxidants
Conflicts
- Proteolytic enzymes (Papain, Bromelain)
- Strong acids (pH < 4.0)
- Strong bases (pH > 8.5)
- High heat (> 45°C)
Safety
Safety Profile
While not formally reviewed by the CIR, it is categorized as a safe skin conditioning agent in the EU. Its peptide structure is generally well-tolerated by the skin's biological systems.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite, scientifically-backed fusion protein that delivers sophisticated wrinkle-relaxing and skin-densifying results when formulated at the correct clinical threshold.
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References
Sources