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CHITOSAN TRIMONIUM CHLORIDE.

Valuable CAS 84777-99-1 / ANTIMICROBIAL, ANTIOXIDANT, BINDING, FILM FORMING, VISCOSITY CONTROLLING

A high-performance cationic derivative of chitosan that creates a breathable, viscoelastic shield on the skin's surface. This biotechnological ingredient bridges the gap between traditional humectants and occlusive barriers, offering long-lasting hydration without a heavy residue.

Film forming Antimicrobial Humectant Barrier protection Active delivery enhancer

Science

Utilizing its inherent positive charge, it electrostatically anchors to the negatively charged proteins of the stratum corneum. This creates a semi-permeable film that prevents trans-epidermal water loss (TEWL) and physically blocks environmental pollutants while simultaneously disrupting microbial cell membranes for a natural antimicrobial effect.


Research

High confidence
Effective range 0.1–2%
Optimal

0.5%

Key findings

  1. 01 Formation of a water-resistant, non-transferable barrier that visibly smooths fine lines and protects against chemical stressors.
  2. 02 Significant enhancement in the deposition and retention of other active ingredients on the skin surface combined with prolonged humectancy.

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Because it is highly effective at concentrations as low as 0.1% for film formation, it is rarely 'dusted' in the traditional sense; however, levels below 0.1% may fail to provide the promised barrier-reinforcement benefits.


The Formula

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Highly stable in aqueous systems and maintains solubility across a wider pH range than standard chitosan, though it excels in slightly acidic environments (pH 4.0–5.5).

Synergies

  • Hyaluronic Acid
  • Glycerin
  • Cationic emulsifiers

Conflicts

  • Anionic surfactants (SLS/SLES)
  • Anionic thickeners (Carbomer, Xanthan Gum)
  • Strongly alkaline environments

Safety

CIR Status
Safe as used
Max tested
15%
Pregnancy
Safe
Sensitization risk Low

Non-sensitizing and non-irritating at clinical levels. Note that this ingredient is derived from shellfish (chitin) and is not suitable for vegan formulations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptional film-former for barrier-compromised skin that excels at keeping moisture in and pollutants out while enhancing the efficacy of accompanying actives.


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