Science
Mechanism of Action
It functions as a cationic polyelectrolyte, where its positive charge binds to the negative charge of skin keratin. This electrostatic interaction creates a semi-permeable film that prevents transepidermal water loss (TEWL) and disrupts microbial cell membranes via pore formation, effectively neutralizing pathogens while maintaining a moist environment for cellular regeneration.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Demonstrated significant acceleration of re-epithelialization and granulation tissue organization in wound healing environments at 1-3% concentrations.
- 02 Achieved a 6-log reduction in S. aureus and E. coli populations within 24 hours at a 2.0% concentration.
Transparency
Dusting Analysis
While often used at lower levels for simple film-forming, clinical results for antimicrobial action and wound healing require at least 1-2%. Products containing less than 0.5% may be 'dusting' the ingredient for label claims without providing its functional restorative benefits.
The Formula
Formulation
Stability
Highly stable in acidic to slightly neutral environments; requires protonation of amino groups to remain soluble and cationic.
Synergies
- Cationic surfactants
- Non-ionic hydrators
- Post-procedure actives
Conflicts
- Anionic surfactants (SLS)
- Anionic thickeners (Carbomer, Xanthan Gum)
- Alkaline conditions (pH > 6.5)
Safety
Safety Profile
Recognized as GRAS (Generally Recognized as Safe). Its components, chitosan and adipic acid, have a long history of safe use in food and medical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile precision ingredient that excels in protecting the skin barrier and managing microbial balance during the healing process.
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References
Sources