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CETYL HYDROXYETHYLCELLULOSE.

Valuable CAS 80455-45-4 / EMULSION STABILISING, FILM FORMING, VISCOSITY CONTROLLING

A sophisticated, plant-derived modified cellulose that functions as a high-performance associative thickener and film-former. It creates a structured, breathable matrix on the skin's surface to enhance the delivery and persistence of active ingredients while providing a silky, non-tacky finish.

Viscosity controlling Emulsion stabilizing Film forming Substantivity enhancer

Science

This molecule utilizes hydrophobic cetyl groups that associate with one another and oil-phase droplets to build a robust, three-dimensional network. This 'associative' behavior allows it to suspend ingredients effectively and form a flexible, non-occlusive film that prevents moisture loss and increases the water and sweat resistance of topically applied formulas.


Research

High confidence
Effective range 0.1–1%
Optimal

0.53%

Key findings

  1. 01 Clinical evaluation of a 0.53% concentration within a polymer network demonstrated a significant increase in skin hydration that persisted for over 8 hours following a single application.
  2. 02 In vivo research confirms its ability to enhance film integrity and sweat resistance, preventing the redistribution or wash-off of active compounds in high-performance formulations.

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

As a viscosity modifier and stabilizer, it is effective at very low concentrations; however, levels below 0.1% may be used purely for marketing ('dusting') rather than for achieving its clinically noted film-forming and hydration benefits.


The Formula

Solubility
Water
Optimal pH 5 – 10
0 7 14

Stability

Highly resistant to enzymatic degradation and microbial breakdown. It exhibits superior tolerance to salts and electrolytes compared to natural gums and features shear-thinning properties for easy spreadability.

Synergies

  • UV filters
  • Humectants
  • Electrolytes

Conflicts

  • pH levels below 3.0
  • High concentrations of anionic surfactants

Safety

CIR Status
Safe as used
Max tested
10%
Pregnancy
Safe
Sensitization risk Low

Classified as non-penetrating and non-irritating by the CIR Expert Panel. Its large molecular size ensures it remains on the skin surface without systemic absorption.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptional stabilizing agent that doubles as a functional active by extending hydration and ensuring formula durability on the skin.


Related

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References