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CETYL GLYCOL ISOSTEARATE.

Valuable CAS 247232-39-9 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

A high-performance emollient ester engineered to function as a biomimetic lipid bilayer structurant. It serves as a sophisticated skin-conditioning agent that reinforces the architectural integrity of the stratum corneum.

Emollient Skin-conditioning agent Lipid bilayer structurant Barrier repair

Science

This ingredient operates by intercalating into the skin's intercellular lipid lamellae. By mimicking natural skin lipids, it increases the packing density of the lipid bilayer, which physically fortifies the moisture barrier against transepidermal water loss (TEWL) and external stressors.


Research

High confidence
Effective range 0.1–15%
Optimal

5%

Key findings

  1. 01 Demonstrated efficacy as a lipid bilayer structurant in topical compositions, significantly enhancing skin hydration through physical reinforcement of the moisture barrier (US Patent 10,980,851).

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

With a functional threshold as low as 0.1%, this ingredient is rarely 'dusted' in a way that negates its barrier-reinforcing properties, though concentrations closer to 1-5% provide more tactile emolliency.


The Formula

Solubility
Oil
Optimal pH 4.5 – 7.5
0 7 14

Stability

Exhibits excellent thermal stability within emulsions but is sensitive to hydrolysis if exposed to extreme acidic or alkaline environments.

Synergies

  • Centella Asiatica
  • Ceramides
  • Fatty Acids
  • Cholesterol

Conflicts

  • Strong oxidizing agents
  • High-concentration Alpha Hydroxy Acids (low pH)
  • Strongly alkaline solutions

Safety

CIR Status
Safe as used
Max tested
15%
Pregnancy
Safe
Sensitization risk Low

Classified under the Alkyl Esters category by the CIR, which concludes the group is safe within current cosmetic practices.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An expertly designed lipid structurant that provides essential structural support to the skin barrier with minimal risk of irritation.


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References