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CETYL ACETATE.

Valuable CAS 629-70-9 / FRAGRANCE, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

A high-performance emollient ester that provides a velvety, non-greasy finish while significantly enhancing the spreadability of topical formulas. It is particularly valued in precision skincare for its dual ability to soften the stratum corneum and act as a lightweight carrier for other active ingredients.

Emollient Skin conditioning agent Penetration enhancer Lubricant

Science

This ingredient functions by creating a breathable, water-repellent occlusive barrier that effectively locks in moisture and prevents trans-epidermal water loss (TEWL). Due to its low viscosity, it serves as a lubricant and penetration enhancer, improving the 'slip' of products and assisting deeper delivery of co-formulated actives.


Research

High confidence
Effective range 0.5–17%
Optimal

6%

Key findings

  1. 01 Demonstrated efficacy in restoring skin capacitance and softness while reducing TEWL in subjects with compromised barriers, such as those with xerosis or atopic dermatitis.
  2. 02 Validated as the maximum safe threshold for leave-on application, showing negligible irritation potential and zero sensitization in human clinical patch testing.

Transparency

Not commonly dusted
Min. effective
0.5%
Red flag below
0.1%

With clinical benefits observed at concentrations as low as 0.5%, it is rarely 'dusted.' However, its secondary role as a texture enhancer means it is often used at 1-3% even when not the primary active.


The Formula

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Thermally stable and resistant to electrolytes. It should be incorporated into the oil phase (melting point 21-23°C). Extremely stable in acidic environments but may undergo slow hydrolysis in highly alkaline conditions.

Synergies

  • Lipophilic actives
  • Mineral oils
  • Vegetable triglycerides

Conflicts

  • Strong oxidizing agents
  • Strongly alkaline solutions (pH > 9.0)

Safety

CIR Status
Safe as used
Max tested
17%
Pregnancy
Safe
Sensitization risk Low

Recognized as GRAS (Generally Recognized as Safe) by the FDA for food use, further reinforcing its safety profile for topical application.


Your Skin

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity High

Our Assessment

Valuable

An excellent textural modifier and barrier-support agent for dry or sensitive skin, though its high comedogenicity makes it less ideal for acne-prone individuals.


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