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CETRIMONIUM SACCHARINATE.

Valuable CAS 2478-29-7 / ANTIMICROBIAL, ANTISTATIC, HAIR CONDITIONING

A specialized quaternary ammonium compound that functions as both a high-performance antimicrobial agent and a surface conditioner. It is primarily utilized in clear liquid formulations to provide a lubricious skin feel and maintain product purity without compromising transparency.

antimicrobial antistatic skin conditioning surfactant

Science

As a cationic surfactant, this molecule carries a permanent positive charge, allowing it to electrostatically bond with negatively charged surfaces such as skin, hair, and microbial cell membranes. It neutralizes static and creates a smooth conditioning film on the skin while simultaneously disrupting the lipid bilayers of bacteria, leading to the leakage of cytoplasmic contents and effective microbial control.


Research

Medium confidence
Effective range 0.1–2%
Optimal

0.25%

Key findings

  1. 01 Evaluation of antimicrobial and antistatic properties in liquid cosmetic preparations (2022)
  2. 02 Safety assessment of trimonium salts and leave-on application thresholds (CIR Expert Panel)

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

In leave-on skincare, concentrations below 0.1% may fail to provide meaningful antimicrobial or conditioning benefits, serving only as a secondary preservative adjunct.


The Formula

Solubility
Water
Optimal pH 4 – 10
0 7 14

Stability

Viscosity typically increases as pH levels drop toward the acidic range; however, the formula may lose clarity in the presence of high salt concentrations or sub-ambient temperatures.

Synergies

  • Non-ionic surfactants
  • Cationic polymers

Conflicts

  • Anionic surfactants (e.g., Sodium Lauryl Sulfate)
  • Soaps
  • Proteins
  • Nitrates
  • Heavy metals
  • Strong oxidants

Safety

CIR Status
Not reviewed
Max tested
0.25%
Sensitization risk Moderate

While related salts are well-studied, this specific saccharinate salt has been noted for insufficient data by the CIR. It is strictly regulated in the EU at a maximum concentration of 0.1% for preservative use.


Your Skin

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Valuable

A precise antimicrobial and conditioning agent for transparent liquid formulas, though it requires careful concentration control to avoid irritation.


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