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Moumoujus

CETRIMONIUM BROMIDE.

Optional CAS 57-09-0 / ANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT - EMULSIFYING

A versatile cationic quaternary ammonium salt that functions as both a powerful antimicrobial and an effective surfactant. It is primarily utilized in precision cleansing formulations to reduce interfacial tension and provide antiseptic properties while maintaining the structural integrity of aqueous systems.

Summary

Antimicrobial Antistatic Surfactant Emulsifying agent Preservative booster

Science

Mechanism of Action

As a cationic molecule, Cetrimonium Bromide carries a permanent positive charge that enables it to bind to negatively charged proteins on the skin and hair. This electrostatic attraction allows it to disrupt the lipid membranes of bacteria and fungi, acting as a preservative booster, while its surfactant properties facilitate the emulsification of oils and debris for efficient removal.

Research

Clinical Evidence

High confidence
Effective range 0.1–0.25%
Optimal

0.25%

Key findings

  1. 01 Human Repeated Insult Patch Tests (HRIPT) conducted by the CIR confirmed no sensitization at a 0.25% concentration, although mild transient irritation was noted during the induction phase.
  2. 02 In vitro research using human HaCaT keratinocytes demonstrated that concentrations between 10-100 μM can induce membrane rearrangement and inhibit ATP synthesis, highlighting the importance of strict concentration limits.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%
Red flag below
0.25%

In leave-on products, this ingredient is strictly regulated; any formulation exceeding 0.25% poses a significant irritation risk and indicates a potential regulatory violation.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7.5
0 7 14

Stability

The molecule maintains its cationic charge across the entire pH spectrum. While it remains stable in alkaline environments, it is most effective and skin-compatible when formulated between pH 5.0 and 7.0.

Synergies

  • Non-ionic surfactants
  • Cationic conditioning agents
  • Phenoxyethanol (preservative synergy)

Conflicts

  • Anionic surfactants (e.g., Sodium Lauryl Sulfate)
  • Anionic polymers/thickeners (e.g., Carbomer, Xanthan Gum)
  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.25%
Pregnancy
Safe
Sensitization risk Moderate

Safe for rinse-off applications at standard levels; however, it is limited to 0.25% in leave-on skincare due to its potential for eye and skin irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Optional

A highly effective functional ingredient for cleansing and microbial control, though its use must be strictly limited to 0.25% in leave-on products to avoid irritation.

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