Science
Mechanism of Action
As an amphiphilic molecule, Cetoleth-5 reduces interfacial tension by orienting its lipophilic cetyl/oleyl tail toward oil droplets and its hydrophilic polyoxyethylene chain toward the water phase. This orientation prevents droplet coalescence and facilitates the gentle emulsification of surface debris, allowing for effective cleansing without aggressive lipid stripping.
Research
Clinical Evidence
High confidence2.5%
Key findings
- 01 Clinical patch testing at a 0.7% concentration demonstrated zero instances of skin irritation across human subjects.
- 02 Safety evaluations at a 5% concentration indicated a threshold for mild irritation, suggesting that formulation concentrations should remain below this limit for sensitive skin applications.
Transparency
Dusting Analysis
As a functional emulsifier rather than a 'hero' active, Cetoleth-5 is rarely 'dusted' for marketing. However, exceeding 5% in a formulation is a red flag for potential irritancy.
The Formula
Formulation
Stability
Possesses a Hydrophile-Lipophile Balance (HLB) of 9.2. It maintains exceptional stability in electrolyte-heavy formulas and hard water environments.
Synergies
- Low HLB co-emulsifiers
- Lipophilic active carriers
- Ethanol-based delivery systems
Conflicts
- Phenolic compounds
- Tannins
- Strong oxidizing agents
Safety
Safety Profile
Safety is contingent on purification processes that minimize 1,4-dioxane and ethylene oxide residues, standard in high-purity cosmetic manufacturing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance stabilizer and mild surfactant that ensures structural integrity in complex emulsions while maintaining a low irritation profile when formulated under 5%.
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References
Sources