Science
Mechanism of Action
By reducing the interfacial tension between aqueous and lipid phases, Ceteareth-5 facilitates the formation of stable emulsions. Its molecular structure allows it to act as a penetration enhancer, temporarily reorganizing the lipid bilayer of the stratum corneum to facilitate the delivery of active ingredients into deeper skin layers.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Clinical patch tests at concentrations of 1.5% and 10.0% demonstrated minimal to no irritation potential and confirmed the ingredient is a non-sensitizer.
- 02 Safety assessments by the CIR representative group indicate that Ceteareths are well-tolerated in repeat-insult dermal applications.
Transparency
Dusting Analysis
As a functional emulsifier rather than a marketing-driven active, Ceteareth-5 is typically used at effective concentrations to maintain formula integrity. It is rarely included at sub-functional levels.
The Formula
Formulation
Stability
Highly resilient to electrolytes and stable across a broad pH spectrum. This waxy solid must be incorporated into the oil phase and heated to 45-50°C for proper melting and integration.
Synergies
- Fatty alcohols
- Nonionic surfactants
- Active molecules requiring enhanced penetration
Conflicts
- Strong oxidizing agents
- Extreme acidity (pH < 3.0)
- Excessive anionic surfactant concentrations
Safety
Safety Profile
While safe for general use, it should be avoided on broken or severely damaged skin to prevent systemic absorption of PEG-related components. Manufacturers must monitor for trace impurities like 1,4-dioxane.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An essential formulation tool that provides both structural stability and enhanced delivery of active ingredients with a low risk of irritation.
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References
Sources