Science
Mechanism of Action
This filtrate operates via a four-pronged pathway: it upregulates Type I collagen and filaggrin synthesis to densify the skin, suppresses MMP-1 enzymes to prevent collagen degradation, inhibits tyrosinase activity to modulate melanin production, and provides comprehensive antioxidant protection by neutralizing free radicals and preventing glycation-induced damage.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 In vitro analysis demonstrated a 65.4% boost in collagen synthesis and a 93.4% reduction in collagenase activity, paired with a 36% increase in filaggrin expression.
- 02 Human clinical trials of a 92.8% concentration over 4 weeks recorded a 14% increase in hydration, a 4% rise in skin density, and a 6% reduction in transepidermal water loss.
Transparency
Dusting Analysis
While highly effective even at concentrations as low as 0.5 mg/mL (approx 0.05% of pure active powder), many mass-market products include it at 'label-only' levels below 0.1% to claim the benefits of fermentation without providing the structural density or hydration improvements seen in clinical data.
The Formula
Formulation
Stability
Highly stable in slightly acidic aqueous environments. It maintains its structural integrity best in minimalist formulas and should be protected from thermal extremes to preserve active proteins.
Synergies
- Sodium Hyaluronate
- Niacinamide
- Panthenol
- Peptides
Conflicts
- Strong oxidizing agents
- Extreme pH environments (<3.5 or >7.5)
- High thermal processing (>45°C)
Safety
Safety Profile
Belongs to the safe category of fungal ferments; in vitro testing confirms zero cytotoxicity in human dermal fibroblasts up to 7 mg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance biotech ingredient that delivers measurable improvements in skin density and barrier function, provided it is used at clinically relevant concentrations.
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References
Sources