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CERAMIDE 6 II.

Essential / HAIR CONDITIONING, SKIN CONDITIONING

Ceramide 6 II is a bio-identical lipid critical for maintaining robust skin barrier function. As a synthetic ceramide, it precisely mimics natural lipids found in the stratum corneum, effectively reinforcing the skin's protective matrix and enhancing its resilience against environmental stressors.

Summary

skin-identical ingredient skin barrier repair moisture retention hydration skin elasticity support environmental protection

Science

Mechanism of Action

This synthetic lipid integrates into the skin's natural lipid matrix, particularly within the stratum corneum, where it contributes to forming a water-impermeable barrier. Ceramide 6 II supports skin barrier resistance by preventing transepidermal water loss and shielding against external aggressors. Its unique alpha-hydroxy group facilitates extra hydrogen bonding, stabilizing the lipid matrix and supporting the skin's vital acid mantle, thus promoting sustained hydration and elasticity.

Research

Clinical Evidence

High confidence
Effective range ≤0.2%
Optimal

0.1%

Key findings

  1. 01 The Cosmetic Ingredient Review (CIR) Expert Panel documented a maximum reported concentration of 0.2% for Ceramide 6 II (also known as Ceramide AP) in leave-on skincare applications.
  2. 02 Formulation guidelines recommend an optimal utilization rate of 0.1% in finished products to effectively support the skin barrier and hydration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 6.5
0 7 14

Stability

Ceramide 6 II demonstrates chemical stability across typical cosmetic pH ranges (4.5-6.5) and is capable of withstanding temperatures up to 90°C. For optimal integration into formulations and to mitigate potential recrystallization or degradation, it is generally advised to incorporate ceramides at or below 40°C. If using powdered ceramide, it should be fully dissolved in a compatible oil by heating to 80-90°C, followed by gradual cooling.

Conflicts

  • highly acidic environments
  • highly alkaline environments

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.2%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Ceramide 6 II (Ceramide AP) is safe for use in cosmetics. It exhibits high biocompatibility and is well-tolerated, even on sensitive or damaged skin. Acute toxicity studies indicate a low risk of severe acute side effects. While generally very mild, some individuals may rarely experience mild irritation, such as temporary redness, itching, or swelling.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

Ceramide 6 II is an essential skin-identical lipid, crucial for fortifying the skin's barrier, enhancing hydration, and improving overall skin resilience and protective function.

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