Science
Mechanism of Action
As an enzyme, Cellulase functions by catalyzing the hydrolysis of β-1,4-glycosidic bonds present in cellulose polymers. While human skin does not inherently contain cellulose, its application in skincare is proposed for its keratolytic action. When incorporated into formulations alongside cellulose, such as in enzyme scrubs, cellulase breaks down the added cellulose, contributing to a visible physical exfoliation effect by promoting the formation of clumps that are subsequently rinsed away.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data available to assess dusting potential or thresholds for this ingredient in cosmetic formulations.
The Formula
Formulation
Stability
Optimal activity of cellulase is typically observed within a pH range of 4.2 to 5.8, with some research indicating a peak around pH 4.8-4.9. The enzyme demonstrates relative stability, retaining over 90% activity, within a broader pH range of 5 to 10. Extremes outside this 5-10 pH window, both below 5 and above 10, can lead to reduced activity and diminished stability. For extended activity over 72 hours, the cellulase system maintains optimal stability between 23°C and 37°C.
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has assessed 'Cellulose, and modified cellulose polymers' as safe for cosmetic use, a specific safety evaluation for the enzyme 'Cellulase' (CAS 9012-54-8) has not been completed by either the CIR or SCCS. The FDA considers CIR findings but does not formally approve individual cosmetic ingredients.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given the absence of specific clinical studies, unknown irritancy, and the lack of a dedicated safety assessment for the enzyme in cosmetic applications, further data is required to fully determine the optimal application and overall safety profile of cellulase.
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References
Sources