Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CELASTRUS PANICULATUS SEED EXTRACT.

Optional / SKIN CONDITIONING

Celastrus Paniculatus Seed Extract is a botanical active offering significant antioxidant and anti-inflammatory properties, alongside potential cytoprotective and skin brightening effects. It functions to protect skin from oxidative stress and inflammation, supporting overall skin health and conditioning.

Summary

Antioxidant Anti-inflammatory Skin Conditioning Cytoprotective Tyrosinase Inhibitor

Science

Mechanism of Action

This extract exerts its effects primarily through potent antioxidant activity, scavenging superoxide anion and hydroxyl radicals to diminish oxidative stress and lipid peroxidation. It also demonstrates anti-inflammatory capabilities by suppressing the production of prostaglandins and other inflammatory cytokines. Furthermore, the seed oil component has shown tyrosinase inhibition activity, potentially aiding in skin tone uniformity, and the extract contributes cytoprotection against DNA damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies on neuronal cells (SH-SY5Y) observed increased cell viability at concentrations of 10 µg/ml in a Parkinson's disease model.
  2. 02 Another in vitro study utilizing a Caenorhabditis elegans model demonstrated neuroprotective effects against dopaminergic degeneration at 9 µg/ml.
  3. 03 For topical application, formulations containing 0.75% w/w of Celastrus paniculatus seed oil, when complexed with 2-hydroxypropyl-β-cyclodextrin, exhibited enhanced skin penetration.
  4. 04 An animal study (Swiss albino murine model) evaluated the extract's chemopreventive potential against skin carcinogenesis when administered orally at 200 mg/kg and 400 mg/kg.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH ≤6.5
0 7 14

Stability

Formulations, including dispersion, serum, and gel, containing a Celastrus paniculatus seed oil complex demonstrated good physical and chemical stability over three months when stored at temperatures of 4, 25, and 45 °C, maintaining a pH of approximately 6.5.

Synergies

  • Enhanced skin penetration when complexed with 2-hydroxypropyl-β-cyclodextrin.

Conflicts

  • Raw Celastrus paniculatus seed oil may leave a difficult-to-remove yellow-orange residue on the skin.
  • Oily formulations of the seed oil may require enhanced delivery methods, such as encapsulation, for optimal active component penetration into the skin.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not conducted a specific safety assessment for Celastrus Paniculatus Seed Extract. The ingredient is recognized as a skin conditioning agent by The Good Scents Company. In vitro studies have indicated no adverse effects on cell viability, even with high concentrations and prolonged exposure.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Celastrus Paniculatus Seed Extract is a promising botanical with demonstrated antioxidant, anti-inflammatory, and cytoprotective mechanisms, making it a valuable optional ingredient for skin conditioning, though direct human topical efficacy requires further investigation.

Related

Similar Ingredients

Finding similar ingredients…