Science
Mechanism of Action
Catalase operates as an oxidoreductase enzyme that facilitates the rapid decomposition of hydrogen peroxide (H2O2) into harmless water (H2O) and molecular oxygen (O2). It boasts one of the highest enzymatic turnover rates known, preventing the accumulation of reactive oxygen species (ROS) that lead to lipid peroxidation and protein carbonylation.
Research
Clinical Evidence
High confidence1.3%
Key findings
- 01 Topical emulsions containing 0.5-3.0% catalase demonstrated significant neutralization of residual hydrogen peroxide on the skin and scalp, mitigating environmental tissue damage.
- 02 Formulations utilizing 1.3% catalase in synergy with yeast extract showed superior enzymatic stability and a sustained reduction of ROS in skin models.
Transparency
Dusting Analysis
Because catalase is a costly and heat-sensitive enzyme, it is frequently included at 'label-claim' concentrations (below 0.1%) where it lacks the enzymatic density required to effectively neutralize oxidative stress. Clinical efficacy requires concentrations starting at 0.5%.
The Formula
Formulation
Stability
Extremely heat-sensitive; activity diminishes rapidly above 40°C. Must not be frozen, as freezing cycles can result in a 50-70% loss of enzymatic function. Peak stability occurs at a neutral pH of approximately 7.0.
Synergies
- Yeast Extract
- Superoxide Dismutase
- Glutathione
Conflicts
- L-Ascorbic Acid (inhibits activity)
- Heavy metals (Copper, Iron)
- Strong anionic surfactants (Sodium Lauryl Sulfate)
- Azides
- Cyanides
Safety
Safety Profile
Recognized as GRAS (Generally Recognized As Safe) by the FDA for food use. While safe for topical application, the enzyme in powder form is a known respiratory sensitizer.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite biological antioxidant that offers unparalleled protection against oxidative damage when formulated within its narrow stability window.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources