Science
Mechanism of Action
Operates as a selective agonist for Cannabinoid Receptor Type 2 (CB2) within the cutaneous layer. This interaction modulates the endocannabinoid system to suppress pro-inflammatory NF-κB and MAPK signaling pathways while simultaneously activating Nrf2-mediated antioxidant defenses and accelerating keratinocyte migration for enhanced barrier recovery.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 A 4.0% concentration was validated via Human Repeated Insult Patch Testing (HRIPT) to be non-irritating and non-sensitizing.
- 02 In vivo analysis of a 1.0% emulgel formulation demonstrated accelerated re-epithelialization and significantly increased collagen remodeling compared to control groups.
- 03 In vitro assays (0.5 µM - 10 µM) confirmed the suppression of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α in keratinocytes.
Transparency
Dusting Analysis
Frequently included at trace levels (<0.1%) solely for its aromatic profile. For biological CB2 activity and wound healing benefits, concentrations should ideally reach or exceed 0.5-1.0%.
The Formula
Formulation
Stability
Exhibits superior oxidative stability compared to beta-caryophyllene. To maintain structural integrity, formulas should be shielded from extreme thermal stress and high-intensity light.
Synergies
- Lipophilic antioxidants
- Ceramides
- Squalane
Conflicts
- Strong oxidizing agents
- Highly alkaline environments (pH > 9.0)
Safety
Safety Profile
Recognized as FEMA GRAS (Generally Recognized As Safe) for food use and recently updated in the 2025 RIFM safety assessments for topical fragrance applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance soothing agent that leverages the skin's endocannabinoid system to accelerate healing and dampen cytokine-induced inflammation.
Related
Similar Ingredients
Finding similar ingredients…