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Moumoujus

CARVONE.

Optional CAS 6485-40-1 / 99-49-0 / 2244-16-8 / FLAVOURING, FRAGRANCE, PERFUMING

A naturally occurring terpene found in spearmint and caraway oils, Carvone is primarily utilized in skincare for its potent antimicrobial properties and its ability to provide a refreshing aromatic profile. Beyond fragrance, it serves as a functional aromatic that helps manage the skin's microbial balance while offering subtle anti-inflammatory benefits.

Summary

Antimicrobial Fragrance Anti-inflammatory Masking

Science

Mechanism of Action

Carvone functions by compromising the structural integrity of microbial cell membranes, leading to the inhibition of fungal and bacterial biofilms. On a cellular level, it modulates phase II detoxification enzymes like glutathione (GSH) and acts as a calcium channel blocker-like agent to soothe smooth muscle tissue, effectively reducing localized inflammatory responses.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–5%
Optimal

0.1%

Key findings

  1. 01 In a large-scale retrospective analysis of over 24,000 subjects, the ingredient showed a very low sensitization rate of 0.78%, classifying it as a weak sensitizer.
  2. 02 In vitro testing confirmed an 86% reduction in fungal polymorphism and significant inhibition of Candida biofilm formation.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.01%
Red flag below
0.001%

Carvone is frequently included at 'dusting' levels purely for its minty scent profile. While effective for fragrance at trace amounts, its antimicrobial and anti-inflammatory benefits require higher concentrations that are often avoided in leave-on products due to its status as a recognized allergen.

The Formula

Formulation

Solubility
Both
Optimal pH 6 – 6.5
0 7 14

Stability

Highly sensitive to alkalinity; degradation occurs rapidly above pH 7.5. It is prone to oxidation and photolysis, requiring UV-protective packaging to prevent conversion into carvone-camphor.

Synergies

  • Antifungal agents
  • Antioxidants (to prevent oxidation)
  • Non-alkaline surfactants

Conflicts

  • Alkaline ingredients
  • Strong oxidizers
  • Direct UV exposure
  • Carbonate-based buffers

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Moderate

Listed as an EU-recognized fragrance allergen. The No Expected Sensitization Induction Level (NESIL) is specifically set at 2600 µg/cm2 to manage contact dermatitis risks.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Optional

While Carvone offers verified antimicrobial benefits and a low comedogenicity profile, its status as a potential allergen makes it an optional inclusion best suited for wash-off products or precise, low-dose aromatic applications.

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