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CARTHAMUS TINCTORIUS SEED EXTRACT.

Valuable CAS 223749-52-8 / SKIN CONDITIONING

A high-performance botanical extract derived from the Safflower plant, prized for its unique concentration of serotonin aglycones and essential fatty acids. This multifunctional ingredient serves as both a biological brightener and a structural lipid replenisher for the skin barrier.

Brightening agent Antioxidant Barrier repair Skin conditioning

Science

The extract operates via a dual-pathway mechanism: it utilizes N-(p-coumaroyl)serotonin to inhibit tyrosinase activity, thereby reducing melanin production, while simultaneously suppressing MMP-1 enzymes to prevent the breakdown of the collagen matrix. Furthermore, its high linoleic acid content integrates into the skin's lipid bilayers to regulate sebum quality and reinforce barrier integrity.


Research

High confidence
Effective range 1–15%
Optimal

5%

Key findings

  1. 01 Demonstrated tyrosinase inhibition and melanin synthesis reduction comparable to arbutin at 1-2% concentrations.
  2. 02 A 92% positive response rate in clinical trials for reducing photoaging signs and providing UVB oxidative protection at 15%.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.1%

While often listed for marketing purposes at trace amounts, clinical data suggests a minimum of 1% is required for pigment-regulating benefits, and higher concentrations are necessary for significant antioxidant protection.


The Formula

Solubility
Both
Optimal pH 4 – 7.5
0 7 14

Stability

Prone to rapid oxidation due to polyunsaturated fatty acid levels; requires stabilization with antioxidants like Tocopherol and protection from light and air.

Synergies

  • Vitamin E (Tocopherol)
  • Arbutin
  • Niacinamide

Conflicts

  • Strong oxidizing agents
  • High thermal processing

Safety

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

While the seed oil is safe up to 100%, the concentrated extract is typically used up to 5% in leave-on formulations according to safety standards.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A highly versatile bio-active that bridges the gap between traditional emollients and modern brightening agents, particularly effective for barrier repair and melanin management.


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