Science
Mechanism of Action
This extract operates through a synergistic blend of Carlina oxide and polyphenolic flavonoids like luteolin and apigenin. It neutralizes free radicals by activating the DAF-16 transcription factor and simultaneously stimulates fibroblast proliferation, the essential process for collagen synthesis and wound healing.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 In vitro analysis (2017) demonstrated that 100 µg/mL significantly boosted fibroblast proliferation without inducing cell death, indicating strong regenerative potential.
- 02 Research in 2024 confirmed potent antibacterial efficacy against MRSA and Bacillus cereus at concentrations between 0.08 and 0.16 mg/mL.
- 03 An in vivo model (2011) showed a 47-64% reduction in oxidative stress markers via anti-stress transcription factor activation.
Transparency
Dusting Analysis
Because clinical efficacy for cellular regeneration begins at very low thresholds (100 µg/mL), many formulations include it at 'label-only' levels below 0.005% which fail to provide the antimicrobial or antioxidant protection shown in research.
The Formula
Formulation
Stability
Contains both polar and non-polar active constituents; stable in hydro-alcoholic and oil-based systems. Highly sensitive to photo-oxidation and must be stored in light-protected packaging.
Synergies
- Vitamin C
- Hyaluronic Acid
- Broad-spectrum antimicrobials
Conflicts
- Strong oxidizing agents
- High pH environments (>8.0)
Safety
Safety Profile
While generally safe in total extract form, the isolated constituent Carlina oxide is toxic at high levels; professional cosmetic extracts are standardized to ensure safety.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective bioactive botanical that excels in skin regeneration and microbial balance when used at scientifically validated concentrations.
Related
Similar Ingredients
Finding similar ingredients…