Science
Mechanism of Action
As a polyanionic derivative, it creates a non-occlusive, breathable film on the skin's surface that prevents trans-epidermal water loss. Its unique negative charge allows it to interact with polar molecules, stabilizing sensitive antioxidants and forming nanomicelles that improve the solubility and targeted delivery of poorly soluble actives into the skin.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Demonstrated >90% inhibition of skin-relevant bacterial growth at concentrations as low as 0.125%-0.25%.
- 02 Proven to significantly increase cutaneous water-holding capacity and reinforce barrier function within a 0.1%-5.0% range.
- 03 Established as a stabilizer for nanomicelles at 1.0%-2.0%, improving the bioavailability of active compounds.
Transparency
Dusting Analysis
Carboxymethyl Dextran remains bioactive at very low concentrations; however, levels below 0.1% are typically insufficient to provide the bacteriostatic or barrier-reinforcing benefits observed in clinical data.
The Formula
Formulation
Stability
Maintains stability across diverse temperatures but loses efficacy in highly acidic environments (pH < 4.0) due to carboxyl protonation.
Synergies
- Vitamin C derivatives
- Antioxidants
- Cationic-sensitive active delivery systems
Conflicts
- Strongly cationic ingredients
- Highly acidic formulas
- Highly oxidative environments
Safety
Safety Profile
Its large molecular weight prevents deep skin penetration, eliminating risks of systemic toxicity and making it exceptionally gentle.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile biopolymer that excels at both protecting the skin barrier and maximizing the efficacy of high-potency active ingredients.
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References
Sources