Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CAPSICUM FRUTESCENS RESIN.

Valuable CAS 8023-77-6 / CLEANSING, FRAGRANCE, TONIC

Derived from the cayenne pepper, this potent resin acts as a thermogenic stimulant that enhances localized microcirculation. It is primarily utilized in high-precision formulations to improve ingredient delivery, stimulate hair follicle activity, and provide localized relief from persistent pruritus.

Summary

Circulation stimulant Antipruritic agent Topical analgesic Follicle activator Penetration enhancer

Science

Mechanism of Action

This ingredient functions as a TRPV1 agonist, stimulating sensory neurons to trigger the release of calcitonin gene-related peptide (CGRP) and substance P. This initial action induces vasodilation and increased blood flow; however, prolonged application leads to the depletion of substance P, resulting in a desensitizing, analgesic, and anti-inflammatory effect. In scalp care, the resulting increase in IGF-1 (insulin-like growth factor-1) serves to prolong the hair follicle's active growth phase.

Research

Clinical Evidence

High confidence
Effective range 0.025–1%
Optimal

0.2%

Key findings

  1. 01 Concentrations of 0.025% to 0.075% significantly reduced pain scores and pruritus in chronic dermatological conditions.
  2. 02 A 0.2% microemulsion formulation demonstrated a 1.27 cm increase in hair growth length over a 30-day period in animal models.
  3. 03 Rabbit skin testing at 0.1% to 1.0% established a safe topical threshold without inducing irritation in non-sensitized subjects.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.025%
Red flag below
0.01%

Because of its high potency, many products include this resin at negligible levels (under 0.01%) purely for 'warming' marketing claims. Clinical efficacy for circulation and hair stimulation requires a minimum threshold of 0.025%.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Thermolabile; exposure to temperatures exceeding 40°C causes carotenoid degradation and scent shifts. Requires UV-protective packaging to maintain potency.

Synergies

  • Vanillyl Butyl Ether
  • Caffeine
  • Niacinamide

Conflicts

  • N-nitrosating agents
  • Strong oxidizing agents
  • pH environments below 4.0

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Moderate

Acts as a penetration enhancer, potentially increasing the systemic absorption of other ingredients. Formulations must be strictly monitored for secondary amine contaminants to prevent the formation of N-nitroso compounds.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Valuable

A high-efficacy stimulant for microcirculation and hair growth, provided it is formulated within a controlled 0.025% to 0.2% range and excluded from sensitive skin regimens.

Related

Similar Ingredients

Finding similar ingredients…