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Moumoujus

CAPSAICINYL SUCCINOYL TRIPEPTIDE-1.

Valuable / ANTIOXIDANT, SKIN PROTECTING

A cutting-edge neuro-cosmetic hybrid that fuses a capsaicin derivative with a signal peptide to revitalize the scalp and skin environment. It bridges the gap between microcirculation enhancement and structural tissue repair without the characteristic irritation of traditional spice extracts.

Summary

Antioxidant Skin protecting Microcirculation stimulant Hair growth factor promoter

Science

Mechanism of Action

This ingredient utilizes a capsaicinyl moiety to engage TRPV1 receptors, boosting blood flow and nutrient delivery to follicles and skin cells without a burning sensation. Simultaneously, the Tripeptide-1 (GHK) component signals the skin to synthesize essential extracellular matrix proteins like collagen and elastin, while the succinoyl bridge ensures deep, stable delivery of these active signals.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–5%
Optimal

3%

Key findings

  1. 01 In vitro testing confirmed a significant increase in VEGF and IGF-1 growth factors within human dermal papilla cells, essential for hair follicle vitality.
  2. 02 A 12-week clinical evaluation of a 3% solution demonstrated a measurable reduction in telogen phase (shedding) hair and enhanced hair anchoring efficacy.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Because it is a complex peptide-derivative, brands often include it at trace amounts (under 0.1%) just for label claims. For genuine scalp revitalization or hair density benefits, concentrations between 1% and 3% are required.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

Highly stable in water-based serums but prone to degradation via hydrolysis if the formula's pH drops below 3.0 or rises above 8.5. Using polyols like glycerin can further stabilize the peptide chain.

Synergies

  • Glycerin
  • Butylene Glycol
  • Panthenol
  • Caffeine

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Extreme pH environments

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

While the specific derivative is awaiting a formal CIR panel review, it is listed as safe in the EU CosIng database and the Tripeptide-1 base is well-documented for its safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A high-performance neuro-peptide that excels in scalp health and hair density formulations by combining circulatory stimulation with structural repair.

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References

Sources