Science
Mechanism of Action
Unlike traditional biocides that kill bacteria and risk microbial resistance, this molecule acts as a non-cidal barrier. It disrupts the physical and chemical adhesion of pathogenic microorganisms, such as Cutibacterium acnes, to the skin surface, preventing them from congregating into biofilms while preserving the skin's healthy commensal flora.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Clinical evaluations of structurally related HLA molecules demonstrate significant reductions in biofilm formation and surface colonization at concentrations as low as 0.075%.
- 02 Research into synergistic acne treatments indicates that when paired with antimicrobial peptides like Oligopeptide-10, it reduces C. acnes colonization without inducing bacterial resistance.
Transparency
Dusting Analysis
Because this ingredient is effective at very low concentrations (peaking at 0.15%), it is rarely 'dusted' in the traditional sense; however, levels below 0.05% may lack the structural density required to effectively inhibit biofilm formation.
The Formula
Formulation
Stability
Maintains high stability in slightly acidic aqueous environments. As a cationic derivative, it is highly compatible with the acidic mantle of acne-prone skin.
Synergies
- Oligopeptide-10
- Non-ionic surfactants
- Cationic conditioners
Conflicts
- Sodium Lauryl Sulfate (SLS)
- Sodium Laureth Sulfate (SLES)
- High-density anionic polymers
- Anionic thickeners
Safety
Safety Profile
Recognized by the EU CosIng database for its favorable safety profile, stemming from its amino acid structure and non-toxic, non-cidal mode of action.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-precision, microbiome-respecting antimicrobial alternative that prevents blemish formation without the risk of antibiotic resistance or irritation.
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References
Sources