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Moumoujus

CAPRYLYL GALLATE.

Valuable CAS 1034-01-1 / ANTIOXIDANT

A high-precision lipophilic ester of gallic acid designed for advanced antioxidant protection and microbial defense. It functions as an ultra-efficient scavenger of reactive oxygen species while providing targeted anti-biofilm activity against pathogenic skin flora.

Summary

Antioxidant Antimicrobial Skin Brightening Preservative Booster

Science

Mechanism of Action

This ingredient operates through a dual-action pathway: it serves as a potent free radical scavenger by inhibiting lipid peroxidation and neutralizing ROS, while simultaneously exerting antimicrobial effects by disrupting the biofilms of S. aureus. Additionally, it offers brightening potential via tyrosinase inhibition and modulates the skin's inflammatory response by reducing pro-inflammatory cytokines like IL-17A and IL-1β.

Research

Clinical Evidence

Medium confidence
Effective range 0.00028–0.1%
Optimal

0.05%

Key findings

  1. 01 Demonstrated 100% abolition of superoxide anion radical production at a concentration of approximately 0.00028% (10 µM).
  2. 02 Showed significant antibacterial activity with a Minimum Inhibitory Concentration (MIC) range of 12.5-50 µg/ml against multiple bacterial species.
  3. 03 Identified a 0.1% concentration as the critical safety threshold for topical application to minimize the risk of allergic contact dermatitis.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.001%
Red flag below
0.0002%

Because Caprylyl Gallate is biologically active at extremely low micro-concentrations (less than 0.001%), it is frequently 'dusted' into formulations to claim antioxidant benefits without providing substantial skin-active results or meaningful formula stabilization.

The Formula

Formulation

Solubility
Oil
Optimal pH 2 – 5
0 7 14

Stability

Requires an acidic environment for stability; prone to rapid hydrolysis and degradation in alkaline conditions. Highly sensitive to air and light exposure.

Synergies

  • Tocopherol
  • Ascorbic Acid

Conflicts

  • Iron salts
  • Alkaline ingredients
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk High

Classified as a Category 1 skin sensitizer. Use must be strictly limited to under 0.1% to avoid allergic contact dermatitis. Removed from EU food additive lists due to data gaps, though cosmetic use remains permitted.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Low

Our Assessment

Verdict

Valuable

An exceptionally potent antioxidant and antimicrobial agent that requires meticulous formulation and strict concentration limits to balance its efficacy with its high sensitization potential.

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