Science
Mechanism of Action
This ingredient functions by interacting with the skin's endocannabinoid system (ECS), specifically binding to CB1 and CB2 receptors located on keratinocytes and sebocytes. This interaction modulates the production of pro-inflammatory cytokines (IL-1β, TNFα) and inhibits matrix metalloproteinases (MMP-1), effectively preventing the enzymatic breakdown of collagen and elastin fibers.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 In vitro analysis demonstrating up to 55% inhibition of collagenase and 30% inhibition of elastase at concentrations as low as 0.01%.
- 02 Hydrogel-based studies showing a measurable reduction in reactive oxygen species (ROS) and a significant increase in epidermal hydration at 0.1% inclusion.
- 03 SCCS safety data confirming a systemic safety profile for dermal applications up to 0.19%.
Transparency
Dusting Analysis
Due to its high marketing appeal, this ingredient is frequently included in 'label-only' concentrations. Formulations containing less than 0.01% likely fail to trigger the enzymatic inhibition required for visible anti-aging or soothing benefits.
The Formula
Formulation
Stability
Highly susceptible to photo-degradation and oxidation; exposure to UV light can convert active cannabinoids into inactive forms like CBN. Must be stored in opaque, airtight delivery systems.
Synergies
- Propanediol
- Glycerin
- Hyaluronic Acid
- Centella Asiatica
Conflicts
- Strong oxidizing agents
- High heat processing (>50°C)
- Highly alkaline environments (pH > 8.0)
Safety
Safety Profile
Regulatory compliance requires THC levels to remain below 0.2% (EU) or 0.3% (US). While safe for general use, clinical data for pregnancy is currently insufficient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical active that offers unique homeostatic benefits through the endocannabinoid system, provided it is used at concentrations above 0.01%.
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