Science
Mechanism of Action
CBG functions as a dual agonist of PPARα/γ and α2-adrenergic receptors while acting as a TRPM8 antagonist to mitigate sensory discomfort. It systematically suppresses pro-inflammatory cytokines—specifically IL-1β, IL-6, IL-8, and TNFα—and inhibits COX-1, COX-2, and iNOS enzymes to arrest lipid peroxidation and neutralize oxidative stress.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 At 0.1%, CBG demonstrates statistically significant reduction in transepidermal water loss (TEWL) and erythema following chemical irritation.
- 02 Gene microarray analysis at 0.5% reveals the modulation of 5,241 genes, including the upregulation of Collagen I, III, IV, and Elastin.
- 03 Safety testing on 3D human skin equivalents confirms a non-irritating profile at concentrations up to 3.0%.
Transparency
Dusting Analysis
CBG is frequently featured in marketing materials but often included at trace amounts. To achieve clinically validated barrier recovery and gene modulation for anti-aging, concentrations should meet or exceed 0.1%.
The Formula
Formulation
Stability
Highly lipophilic and sensitive to photo-oxidation and thermal degradation; must be protected from light and air. Exposure to alkaline environments (pH > 7.0) causes deprotonation, which may result in a purple color shift.
Synergies
- Ceramides
- Squalane
- Tocopherol
- CBD
Conflicts
- Strong oxidizing agents
- Strong acids
- Strong bases
- High-heat manufacturing processes
Safety
Safety Profile
While human skin equivalent tests show zero irritation at 3.0%, the regulatory landscape is evolving; currently listed as a priority for CIR and SCCS evaluation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-potency cannabinoid that outperforms CBD in collagen stimulation and redness reduction, making it an essential active for barrier-focused precision skincare.
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References
Sources