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CANDIDA ALBICANS/FRITILLARIA VERTICILLATA BULB FERMENT EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A sophisticated biotechnological fusion of traditional Hanbang medicine and yeast fermentation. This bioactive extract leverages the strengthening properties of Fritillaria bulbs, transformed through fermentation into a potent repairing agent for compromised skin barriers.

barrier repair anti-inflammatory brightening microbiome balancing antioxidant

Science

This ingredient operates through a dual-action pathway: isosteroidal alkaloids (peimine and peiminine) suppress inflammatory cascades (NF-κB/MAPK) and collagen-degrading enzymes (MMP-1), while yeast-derived glycolipids act as natural biosurfactants. These metabolites enhance the penetration of antioxidants and stimulate cellular autophagy, essentially 'recharging' the skin's internal detoxification and renewal systems.


Research

High confidence
Effective range 0.5–5%
Optimal

2%

Key findings

  1. 01 Demonstrated tyrosinase inhibition comparable to arbutin for targeted skin brightening.
  2. 02 Significant reduction in pro-inflammatory cytokines IL-6 and TNF-α in human keratinocytes.
  3. 03 Production of glycolipid biosurfactants proven to restore microbiome balance and moisture retention.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Due to its high cost and association with luxury Hanbang brands, it is frequently used at 'claim levels' (0.1% or less). To achieve the documented anti-inflammatory and barrier-repair benefits, a concentration of at least 0.5% is required.


The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Thermolabile; must be incorporated during the cooling phase (below 40°C) to maintain the structural integrity of the alkaloids and ferment lysates.

Synergies

  • Arbutin
  • Niacinamide
  • Hyaluronic Acid
  • Ceramides

Conflicts

  • Strong oxidizing agents
  • Anionic surfactants (>5%)
  • High ethanol content (>20%)

Safety

CIR Status
Safe as used
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Classified as a non-pathogenic yeast-derived lysate; it contains no live Candida albicans cultures and is verified for safety in topical applications.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A high-performance multifunctional ferment that excels at calming systemic inflammation while simultaneously brightening and shielding the skin barrier.


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