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Moumoujus

CAMELLIA SINENSIS CALLUS CULTURE LYSATE.

Valuable / ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

A high-precision biotechnological extract derived from the laboratory-cultured stem cells of Green Tea, processed via lysis to release bioavailable polyphenols and catechins. This advanced ingredient provides targeted cellular protection and microbiome modulation, offering a more concentrated bioactive profile than traditional leaf extracts.

Summary

antioxidant microbiome balancer anti-inflammatory collagen protector

Science

Mechanism of Action

This ingredient operates through a four-tier pathway: it inhibits NF-κB nuclear translocation to suppress pro-inflammatory cytokines (IL-6, IL-8); disrupts C. acnes biofilm formation by blocking quorum sensing (AI-2 signaling); neutralizes reactive oxygen species (ROS) via concentrated catechins; and prevents protein glycation (AGEs) while inhibiting matrix metalloproteinases to preserve the structural integrity of the collagen matrix.

Research

Clinical Evidence

High confidence
Effective range 0.1–5%
Optimal

2.5%

Key findings

  1. 01 Concentrations as low as 0.25% significantly reduce pro-inflammatory cytokine production in keratinocytes.
  2. 02 A 2.5% to 5.0% range effectively blocks bacterial quorum sensing and inhibits C. acnes biofilm formation without bactericidal effects.
  3. 03 Usage between 0.1% and 5.0% has been shown to protect dermal fibroblasts from UV damage and promote collagen secretion.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.25%
Red flag below
0.1%

While many formulas include this ingredient at trace amounts for marketing, clinical efficacy for inflammatory regulation begins at 0.25%, and microbiome-balancing benefits require concentrations closer to 2.5%.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6
0 7 14

Stability

Highly sensitive to light and oxidation; browning may occur at alkaline pH or upon air exposure. Formulation should be kept in opaque, airtight packaging.

Synergies

  • Antioxidants
  • Soothing agents
  • Collagen-boosting peptides

Conflicts

  • Strong oxidizing agents
  • Ferric salts
  • Alkaline environments (pH > 7.0)

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

While standard Camellia sinensis leaf extracts are well-established, callus-derived lysates were noted by the CIR in 2014 as needing further sensitization data at high concentrations; however, current industry use under 5% is widely considered safe and non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A sophisticated multi-tasker that uniquely balances the microbiome through anti-quorum sensing while providing robust anti-inflammatory and anti-aging benefits.

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