Science
Mechanism of Action
This ingredient mimics the structure of human ceramides 2, 4, and 5, allowing it to integrate seamlessly into the intercellular lipid matrix. By enhancing the cohesion between corneocytes, it effectively repairs the skin barrier, optimizes the epidermal water-holding capacity, and forms a non-occlusive film that limits trans-epidermal water loss (TEWL).
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Clinical evaluation at 0.5% concentration demonstrated significant antipsoriatic activity and measurable improvements in microscopic skin morphology over a 21-day period.
- 02 In vitro testing showed that concentrations between 0.1% and 2.5% increased metabolic activity in fibroblasts and keratinocytes, reducing cellular damage from harsh surfactants by up to 15%.
Transparency
Dusting Analysis
Because it is effective at very low concentrations (0.1%), many formulations include it at 'label claim' levels (under 0.05%) which may provide emolliency but fail to trigger the biological barrier repair and cellular viability benefits seen in clinical data.
The Formula
Formulation
Stability
Highly stable across a broad pH range and resistant to electrolyte-induced degradation; maintains a clear to slightly opaque liquid state at room temperature.
Synergies
- Ectoine
- Anionic surfactants
- Cholesterol
- Fatty acids
Conflicts
- Strong oxidizing agents
- High ethanol concentrations (potential emulsion instability)
Safety
Safety Profile
Recognized by EU CosIng as a safe, non-sensitizing ingredient for leave-on applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional biomimetic lipid that provides genuine barrier restoration and cytoprotection when formulated at active concentrations above 0.1%.
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References
Sources