Science
Mechanism of Action
This extract operates through a dual-action pathway: first, it activates the FUNDC1-mediated mitophagy process, which identifies and removes damaged mitochondria to optimize cellular energy; second, it upregulates the production of Type III collagen and Claudin-1 proteins to reinforce the skin's architecture and moisture barrier.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 In vitro analysis confirms DNA damage repair and enhanced fibroblast viability via the mitophagy pathway at concentrations as low as 0.224 μg/mL.
- 02 Upregulation of elastin and Claudin-1 demonstrated in structural integrity assays.
- 03 Clinical volunteer testing showed significant reductions in redness and sebum levels with a 0.5% concentration.
Transparency
Dusting Analysis
Because biological activity begins at extremely low concentrations (0.002%), many formulations include it at 'label claim' levels that lack the potency required for significant barrier repair and collagen stimulation, which typically require higher inclusion rates.
The Formula
Formulation
Stability
Highly sensitive to thermal degradation and photo-oxidation. Must be incorporated during the cooling phase below 40°C and stored in UV-protective packaging.
Synergies
- Vitamin E
- Glycerin
- UV Filters
Conflicts
- Strong oxidizing agents
- High pH formulations (>7.0)
Safety
Safety Profile
Safe for leave-on use up to 0.86%. Its established use in tea-related ingredients supports its excellent systemic safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional bioactive for cellular maintenance and barrier repair, provided it is formulated within the 0.1% to 0.86% range to maximize structural benefits.
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References
Sources