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Moumoujus

CALOPHYLLUM TACAMAHACA SEED OIL.

Valuable CAS 223748-12-7 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

A potent bio-active lipid extracted from the nuts of the Tamanu tree, renowned for its dual-action ability to accelerate tissue regeneration and provide significant photoprotection. This high-viscosity oil is distinguished by its unique resinous content which facilitates deep structural repair of the skin barrier.

Summary

Photoprotective Collagen Stimulant Antimicrobial Anti-inflammatory Cicatrizing (Wound Healing)

Science

Mechanism of Action

The oil utilizes a complex matrix of calophyllic acid and calophyllolide to trigger keratinocyte proliferation and collagen synthesis at the cellular level. It exerts anti-inflammatory control by inhibiting proteinase K and 15-LOX enzymes, while its neoflavonoids provide targeted antimicrobial defense by disrupting bacterial membranes and stimulating the skin's innate immunity through β-defensin 2 induction.

Research

Clinical Evidence

High confidence
Effective range 0.01–1%
Optimal

1%

Key findings

  1. 01 In vitro testing at a 1% concentration demonstrated an 85% inhibition of UV-induced DNA damage across the 260-400 nm spectrum.
  2. 02 Application at 1% concentration yielded a 350% increase in glycosaminoglycans (GAGs) and a 40% boost in collagen production in human fibroblasts.
  3. 03 Minimal Inhibitory Concentrations (MIC) as low as 0.01% were found effective against P. acnes, showing performance comparable to pharmaceutical-grade antibiotics.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.1%

While many formulas include this oil for its marketing appeal as 'Tamanu Oil,' its primary regenerative benefits for collagen and DNA protection require a concentration of at least 1%. Formulations using it below 0.1% likely only provide basic emolliency rather than clinical bio-activity.

The Formula

Formulation

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

Highly sensitive to thermal degradation; bioactive calophyllolides may break down if exposed to high heat during emulsification. Requires secondary antioxidants like Tocopherol and UV-protective packaging to prevent oxidation of unsaturated fatty acids.

Synergies

  • Vitamin E (Tocopherol)
  • Retinoids
  • Hyaluronic Acid (complements GAG stimulation)

Conflicts

  • Strong oxidizing agents
  • High-heat processing

Safety

Safety Profile

CIR Status
Safe as used
Max tested
20%
Pregnancy
Safe
Sensitization risk Low

Derived from tree nuts; individuals with known nut allergies should exercise caution. No specific regulatory limits are established by the FDA beyond general cosmetic safety.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Moderate

Our Assessment

Verdict

Valuable

A high-performance botanical lipid that bridges the gap between traditional emolliency and clinical regenerative medicine.

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References

Sources