Science
Mechanism of Action
This extract functions through its rich profile of flavonoids (luteolin, apigenin) and diterpenes (calliterpenone). These compounds stabilize cell membranes to prevent heat-induced protein denaturation, effectively curbing inflammation. Additionally, it acts as a radical scavenger against DPPH and nitric oxide while providing antimicrobial support to purify the skin microbiome.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 In vitro studies demonstrate significant anti-inflammatory activity with an IC50 of 288.04 µg/ml by inhibiting albumin denaturation.
- 02 Antioxidant potential confirmed through nitric oxide radical scavenging with an IC50 of 302.93 µg/ml.
- 03 Exhibits broad-spectrum antibacterial activity against S. aureus and B. subtilis at concentrations between 200-400 µg/ml.
Transparency
Dusting Analysis
Due to its botanical nature, many formulations include this extract at 'label-only' concentrations. Since its IC50 for antioxidant and anti-inflammatory activity begins around 288-302 µg/ml, levels below 0.05% (500 µg/ml) may fail to deliver measurable physiological benefits.
The Formula
Formulation
Stability
Highly stable in poly-herbal emulsions and oil-in-water (O/W) systems. It maintains efficacy in both aqueous and ethanolic extraction formats.
Synergies
- Vitamin E
- Niacinamide
- Soothing botanicals
Conflicts
- Strong oxidizing agents
Safety
Safety Profile
While not formally reviewed by the CIR, it has a documented history in traditional medicine. Toxicological data in animal models shows no mortality at high oral doses (200mg/kg), supporting its safety profile for topical use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An excellent botanical for comprehensive skin protection and purification, provided it is formulated at concentrations high enough to reach its demonstrated IC50 thresholds.
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References
Sources