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Moumoujus

CALCIUM TRIFLUOROACETATE.

Questionable CAS 60884-90-4 / ABRASIVE

A sophisticated multi-functional salt that provides targeted chemical exfoliation while simultaneously addressing vascular-driven redness. It is particularly valued in high-performance formulations for its dual ability to refine skin texture and modulate the signaling pathways associated with persistent flushing.

Summary

Exfoliant Anti-angiogenic agent Abrasive Texture Refiner

Science

Mechanism of Action

This ingredient operates via two distinct pathways: it utilizes the trifluoroacetate group to break down desmosomal bonds for effective keratolysis, and it acts as an anti-angiogenic agent by inhibiting calcium entry into endothelial cells, thereby blocking Vascular Endothelial Growth Factor (VEGF) signaling to reduce unwanted neovascularization.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–20%
Optimal

5%

Key findings

  1. 01 Demonstrated significant reduction in hyperkeratotic lesions and skin thickening at concentrations between 5-10%.
  2. 02 In-vitro evidence confirms the inhibition of endothelial growth factor signaling, suggesting efficacy for rosacea-prone skin.
  3. 03 Identified as effective for active skin benefits in hair and skin care at levels ranging from 0.25% to 2%.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.25%
Red flag below
0.1%

While commercial products often include this at levels as low as 0.006%, therapeutic keratolytic benefits typically require concentrations above 0.25%, with optimal textural refinement appearing at much higher percentages (5%+).

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 4.5
0 7 14

Stability

Thermally sensitive; begins decomposition at 106°C. Must be formulated in aqueous environments and kept away from high-heat processing.

Synergies

  • Low-pH surfactants
  • Chelating agents
  • Soothing anti-inflammatories

Conflicts

  • High temperatures (>100°C)
  • Strong bases
  • Highly reactive nucleophiles

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Moderate

Currently categorized by the FDA as a PFAS due to its fluorinated structure, leading to increased regulatory oversight. While generally well-tolerated topically, its long-term environmental and systemic profile is under scrutiny.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Questionable

While a potent dual-action exfoliant and anti-redness active, its classification as a PFAS and lack of extensive CIR safety data make it a controversial choice for modern precision skincare.

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References

Sources