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CALCIUM PYROPHOSPHATE.

Valuable CAS 7790-76-3 / ABRASIVE, ORAL CARE

A multifunctional mineral salt that serves as both a precision mechanical exfoliant and a sophisticated delivery vehicle for active ingredients. Its unique crystalline structure allows for gentle resurfacing while supporting the skin's structural integrity through the release of essential calcium ions.

Abrasive Exfoliant Active Delivery Vehicle Opacifying Agent

Science

It functions primarily as a mild physical abrasive to sweep away dead corneocytes and surface pollutants via controlled friction. In advanced skincare, it acts as a nanoporous carrier, shielding unstable actives like retinoids and facilitating their sustained release into the dermis while concurrently providing calcium to assist in barrier repair and epidermal differentiation.


Research

High confidence
Effective range 1–5%
Optimal

3%

Key findings

  1. 01 A 4 to 8-week clinical trial utilizing a 1.0%-5.0% concentration within a delivery system resulted in 96% of participants observing measurable improvements in skin plumpness and texture smoothness.
  2. 02 Long-term subchronic toxicity evaluations confirm its safety for systemic exposure and lack of toxicological potential when applied topically.

Transparency

Commonly dusted
Min. effective
1%
Red flag below
0.5%

Often listed in trace amounts to claim 'exfoliating' benefits on the label, but concentrations below 1% are insufficient to provide the mechanical friction or the delivery system benefits observed in clinical settings.


The Formula

Solubility
Unknown
Optimal pH 4 – 9
0 7 14

Stability

Insoluble in both water and oil; it remains as suspended particles within a formula. While stable in neutral to alkaline environments, it may destabilize or dissolve if the pH drops below 3.0.

Synergies

  • Retinaldehyde
  • Barrier-repair lipids
  • Humectants

Conflicts

  • Cationic surfactants
  • Polyquaternium-10
  • Strong Alpha Hydroxy Acids (pH < 3.0)

Safety

CIR Status
Safe as used
Max tested
50%
Pregnancy
Safe
Sensitization risk Low

Recognized as safe by the CIR Expert Panel (2021). While used at very high levels in oral care, leave-on skincare applications are typically capped at 5% to ensure the formula remains non-irritating.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An excellent dual-purpose ingredient that provides safe physical resurfacing and enhances the efficacy of potent actives through its unique delivery system properties.


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References