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Ingredient directory

Calcium Peroxide

A potent inorganic oxidizing agent that functions as a stabilized source of active oxygen. Primarily used in professional oral care and clinical wound-healing applications, it provides targeted antimicrobial action and pigment oxidation.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

oxidising bleaching antimicrobial oxygen-generating

Science

Mechanism of Action

Upon contact with moisture, calcium peroxide undergoes hydrolysis to release oxygen (O2) and hydrogen peroxide (H2O2). This reaction produces reactive oxygen species (ROS) that dismantle bacterial cell membranes and oxidize organic stains (chromogens). In clinical wound models, it has been shown to modulate inflammatory responses and stimulate angiogenesis to accelerate tissue repair.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–6%
Optimal

0.5%

Key findings

  1. 01 Ayad et al. (1999) demonstrated that 0.5% concentration significantly diminished extrinsic dental staining over a 6-week period.
  2. 02 Mohammed et al. (2023) found that 6.0% concentrations inhibited bacterial growth and enhanced fibroblast proliferation in regenerative medicine models.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Because of strict EU regulations limiting free hydrogen peroxide to 0.1% in oral products, manufacturers often include calcium peroxide at negligible levels that may not provide the 0.5%+ concentration required for significant oxidative brightening.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Extremely sensitive to moisture; it decomposes rapidly in humid air or acidic environments. To maintain efficacy, it must be kept in anhydrous (water-free) or solid-state formats.

Conflicts

  • Water
  • Acids
  • Bases
  • Heavy metal salts
  • Reducing agents
  • Organic materials

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk High

Classified as a GHS Category 2 skin irritant and Category 1 eye damager. Use is restricted by the SCCS (EU) in oral care products to ensure free hydrogen peroxide remains below 0.1%.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Low

Our Assessment

Verdict

Questionable

While effective for oral brightening and clinical wound healing, its high irritation potential and extreme instability in water make it unsuitable for conventional skincare.

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