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CALCIUM DIHYDROGEN PHOSPHATE.

Valuable CAS 7758-23-8 / BUFFERING

A multifunctional mineral salt that serves as both a precise pH buffer and a bioavailable source of essential skin minerals. It is utilized in advanced dermatological formulas to stabilize acidic environments while providing therapeutic relief for compromised skin barriers.

Buffering Agent Skin Conditioner Mild Abrasive pH Adjuster Viscosity Controller

Science

This ingredient functions as a pH regulator that resists chemical shifts to maintain formula integrity. Upon topical application, it dissociates into calcium and phosphate ions, which assist in repairing the skin’s mineral matrix and strengthening the acid mantle; it can also act as a non-aggressive physical polisher or a reactant in effervescent systems.


Research

High confidence
Effective range 0.1–3%
Optimal

2%

Key findings

  1. 01 Clinical evaluation of a 2.0% concentration demonstrated an 80% reduction in cutaneous erythema (redness) over a 10-day period.
  2. 02 Application in inflammatory conditions showed a 90% decrease in pain and exudation associated with eczema and psoriasis after 4-6 uses.
  3. 03 Research indicates a significant improvement in surface texture and remineralization of hard tissues at concentrations between 0.1% and 3.0%.

Transparency

Not commonly dusted
Min. effective
0.5%
Red flag below
0.1%

While often used as a simple buffer at low levels, clinical benefits for skin soothing and barrier repair require concentrations closer to 2.0%. Formulas claiming therapeutic benefits at levels below 0.5% may be under-dosing the active mineral potential.


The Formula

Solubility
Water
Optimal pH 3 – 6
0 7 14

Stability

Exhibits peak stability in acidic environments; solubility is inversely proportional to pH. It may precipitate if the formula becomes too alkaline or in the presence of specific chelators.

Synergies

  • Carbonates (for effervescent effects)
  • Mild surfactants
  • Humectants

Conflicts

  • Sodium bicarbonate
  • Strong bases
  • High-proof ethanol

Safety

CIR Status
Safe as used
Pregnancy
Safe
Sensitization risk Low

Recognized as FDA GRAS (Generally Recognized as Safe) and concluded safe by the CIR Expert Panel when formulated to minimize irritation.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptionally effective mineral stabilizer for sensitive and reactive skin, particularly when used at 2.0% to target redness and barrier dysfunction.


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References