Science
Mechanism of Action
By providing bioavailable calcium ions (Ca2+), this ingredient restores the precise concentration gradient required for epidermal health. It signals the maturation of keratinocytes and the production of vital skin lipids like ceramides, ensuring the cornified envelope—the skin's primary shield—is resilient and well-formed.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Demonstrated role in supporting keratinocyte differentiation and epidermal homeostasis within a 1-3% range (CIR).
- 02 Confirmed high skin tolerability and lack of hypersensitivity even in polyvalent cation complexes up to 20% (Patent WO2013013999A2).
Transparency
Dusting Analysis
To actively support the calcium gradient and influence barrier repair, concentrations below 1% are generally insufficient to provide functional mineral signaling.
The Formula
Formulation
Stability
Optimal stability occurs in near-neutral to slightly acidic aqueous environments. Stability is compromised below pH 4.0, where the aspartic acid component may dissociate.
Synergies
- Amino acids
- Ceramides
- Humectants
Conflicts
- Strong chelators (e.g., Disodium EDTA)
- High concentrations of anionic surfactants
- Extreme pH levels outside 4.0-8.5
Safety
Safety Profile
Classified as safe by the CIR Expert Panel; typically formulated up to 3% in high-performance leave-on products to ensure maximum biocompatibility.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A precise, low-irritancy mineral complex essential for restoring the biological signals required for a robust and self-repairing skin barrier.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources