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Moumoujus

CAFFEOYL SH-HEPTAPEPTIDE-13.

Valuable / ANTIOXIDANT, SKIN PROTECTING

A sophisticated bio-engineered conjugate that merges the antioxidant power of Caffeic Acid with a high-performance signaling peptide. This hybrid molecule is designed to simultaneously neutralize oxidative stress and stimulate the structural proteins necessary for skin density.

Summary

antioxidant skin protecting collagen synthesis inducer anti-aging matrix protection

Science

Mechanism of Action

This ingredient operates through a dual-action pathway: the sh-Heptapeptide-13 portion acts as a biomimetic of Angiotensin 1-7, binding to Mas receptors to trigger cellular proliferation and collagen synthesis. Concurrently, the Caffeoyl moiety functions as a potent antioxidant, scavenging reactive oxygen species (ROS) and inhibiting matrix metalloproteinases (MMPs) to prevent the enzymatic breakdown of the skin's extracellular matrix.

Research

Clinical Evidence

High confidence
Effective range 0.001–2%
Optimal

1.5%

Key findings

  1. 01 In vitro analysis confirms significant induction of collagen synthesis and protection against UV-induced oxidative stress at concentrations as low as 0.001% of the active peptide.
  2. 02 Human clinical trials using a 1-2% commercial solution demonstrated a measurable reduction in wrinkle depth and enhanced skin elasticity over a 4 to 8-week period.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.1%

Because peptides are effective at very low micro-concentrations, they are frequently 'dusted' into formulas at sub-clinical levels for marketing purposes. For visible structural improvements in wrinkles and elasticity, a commercial solution concentration of at least 1% is typically required.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

The molecule is heat-sensitive and must be incorporated during the cool-down phase of formulation (below 40°C) to avoid denaturation. It remains stable within physiological pH ranges.

Synergies

  • Hyaluronic Acid
  • Niacinamide
  • Non-proteolytic antioxidants

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Extreme pH environments (below 4.0 or above 8.0)

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Classified as a synthetic peptide/protein; recognized as safe for cosmetic applications and listed in the EU CosIng database without specific restrictions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An innovative hybrid ingredient that provides excellent multi-functional benefits for aging and environmentally stressed skin when used at clinical levels.

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References

Sources