Science
Mechanism of Action
This ingredient functions as a melatonin-like messenger that interacts with the skin's MT1 and MT2 receptors. By synchronizing the circadian rhythm at a cellular level, it optimizes the skin's natural repair cycle, neutralizes oxidative stress, and restores biological balance to tissues disrupted by external stressors or sleep deprivation.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Clinical data indicates that concentrations between 1.0% and 2.0% effectively revive deep biological functions and synchronize circadian rhythms to correct age-related physiological processes.
Transparency
Dusting Analysis
As a specialty biotech ingredient often marketed under trade names like Millesis, it is frequently included at sub-clinical levels (<1.0%) for marketing claims regarding 'melatonin-like' effects without providing the necessary receptor-level synchronization.
The Formula
Formulation
Stability
Demonstrates high stability across a wide pH range and is notably resistant to electrolytes. Its amphiphilic nature allows for seamless integration into both aqueous and emulsion-based systems.
Synergies
- Caffeic Acid
- Niacinamide
- Hyaluronic Acid
- Peptides
Safety
Safety Profile
Currently listed on the EU's INCI inventory (CosMile). While formal CIR assessment is pending, it is utilized in global commercial formulations with an established profile of safety and non-irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional precision ingredient for overnight recovery and anti-fatigue formulations, provided it is used at the clinically validated threshold of at least 1%.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources