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C14-18 GLYCOL.

Valuable CAS 223239-96-1 / EMULSION STABILISING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

A long-chain lipophilic vicinal diol that serves as a multifunctional lipid-mimetic emollient and stabilizer. It bridges the gap between traditional solvents and structural lipids to enhance both formula resilience and skin barrier integrity.

emollient emulsion stabilizer photostabilizer skin-conditioning agent

Science

As a large-molecule lipophilic glycol, it integrates into the skin's lipid bilayer to fill intercellular voids and create a smoother surface texture. Beyond simple emolliency, it stabilizes emulsions by reducing interfacial tension and optimizes the dielectric constant of the oil phase, which prevents the degradation of volatile UV filters and improves overall photostability.


Research

High confidence
Effective range 0.5–15%
Optimal

5%

Key findings

  1. 01 Significant reduction in transepidermal water loss (TEWL) achieved through the promotion of ortho-rhombic lamellar crystalline structures in the skin barrier.
  2. 02 Acts as a photostability booster for UV filters, specifically improving the SPF/PFA ratio in sunscreen systems.
  3. 03 Large-scale patch testing (n=224) confirmed a lack of Type IV dermal reactions, demonstrating exceptional skin compatibility.

Transparency

Not commonly dusted
Min. effective
0.5%
Red flag below
0.1%

C14-18 Glycol is rarely 'dusted' because it serves a functional role in emulsion stability; however, concentrations below 0.5% may fail to provide the meaningful barrier support and photostabilization benefits found in clinical research.


The Formula

Solubility
Oil
Optimal pH 3 – 9
0 7 14

Stability

Exhibits excellent thermal and hydrolytic stability across a broad pH spectrum, making it ideal for both acidic and alkaline formulations.

Synergies

  • Avobenzone
  • UV Filters
  • Ceramides
  • Plant Oils

Conflicts

  • Carbomer (may reduce viscosity at high concentrations)

Safety

CIR Status
Safe as used
Max tested
40%
Pregnancy
Safe
Sensitization risk Low

While safe up to 40% per CIR guidelines, standard cosmetic efficacy is reached at levels under 10%.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An expertly engineered lipid that provides dual benefits of clinical barrier reinforcement and advanced sunscreen stabilization.


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