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Ingredient directory

Butyldimoniumhydroxypropyl Laurylglucosides Chloride

A naturally-derived polymeric quaternary ammonium compound that combines the conditioning benefits of traditional quats with superior gentleness through its sugar-based backbone. This innovative surfactant provides effective cleansing and conditioning while maintaining exceptional compatibility with sensitive skin formulations.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

conditioning agent surfactant cleansing antistatic

Science

Functions via its positively charged quaternary ammonium group that electrostatically binds to negatively charged keratin surfaces, creating substantive conditioning effects. The polymerized alkyl polyglucoside backbone forms a moisturizing film that significantly reduces irritation potential compared to conventional monomeric quaternary compounds.


Research

High confidence
Effective range ≥4%
Optimal

4%

Key findings

  1. 01 48-hour occlusive patch testing (n=53): No dermal irritation at 4.0% concentration
  2. 02 HET-CAM ocular irritation assessment: Score 13.25 for undiluted material, indicating moderate eye irritation potential but significantly lower than traditional quaternary compounds
  3. 03 Human Repeat Insult Patch Testing demonstrated absence of sensitization potential

Transparency

Not commonly dusted

Primarily used in hair care and cleansing formulations rather than skincare products where dusting would be a concern


The Formula

Solubility
Water
Optimal pH 4.5 – 8
0 7 14

Stability

Exceptionally stable in aqueous systems with thermal stability up to 50°C during processing. Uniquely compatible with anionic surfactants unlike traditional quaternary compounds.

Synergies

  • Anionic surfactants
  • Sugar-based cleansing agents

Safety

CIR Status
Not formally reviewed as standalone ingredient, classified as Polyquaternium-78
Sensitization risk Low

Polymeric quaternary ammonium compounds are generally considered safe due to large molecular size and limited dermal penetration. EU Cosmetic Regulation 1223/2009 compliant.


Your Skin

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An innovative gentle alternative to traditional quaternary compounds with proven safety and unique anionic compatibility, though primarily suited for cleansing rather than leave-on skincare applications.


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