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Moumoujus

BROUSSONETIA KAZINOKI ROOT EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A botanical extract from paper mulberry root that delivers potent skin brightening effects through tyrosinase inhibition with reduced irritation compared to traditional lightening agents. Rich in prenylated flavonoids like Kazinol F, this extract offers multi-functional benefits including antioxidant protection and anti-inflammatory activity. Clinical evidence demonstrates efficacy comparable to hydroquinone while maintaining superior tolerability across all skin types.

Summary

Skin brightening Antioxidant Anti-inflammatory Soothing

Science

Mechanism of Action

Inhibits tyrosinase enzyme activity through prenylated flavonoids (particularly Kazinol F with IC50 of 0.396 µg/mL) to reduce melanin production, while simultaneously suppressing NF-κB signaling pathways for anti-inflammatory effects and scavenging reactive oxygen species for antioxidant protection

Research

Clinical Evidence

High confidence
Effective range 1–2%
Optimal

2%

Key findings

  1. 01 24-participant clinical trial showing 1.0% Kazinol F significantly reduced UVB-induced pigmentation with efficacy matching hydroquinone
  2. 02 KFDA registration at 2.0% concentration for functional skin-whitening applications

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Given the established 1-2% effective concentration range and KFDA registration requirements, formulations below 0.1% likely provide minimal brightening benefit

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 8
0 7 14

Stability

Highly photosensitive and thermolabile; requires protection from light and heat. Stability improved through encapsulation in polymeric microspheres or O/W emulsions with antioxidants.

Synergies

  • Antioxidants (for stability)
  • Niacinamide
  • Vitamin C

Conflicts

  • Strong oxidizing agents
  • Formulations below pH 4.0

Safety

Safety Profile

CIR Status
Not yet reviewed (on CIR priority assessment list)
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Recognized as safe botanical in EU and South Korea. EWG Skin Deep rates as 1 (Low Hazard). No significant safety concerns reported in clinical applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A clinically-validated brightening agent that offers hydroquinone-level efficacy with superior tolerability and multi-functional skin benefits.

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