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Moumoujus

BROMOTHYMOL BLUE.

Insufficient Data CAS 76-59-5 / COLORANT

A sulfonephthalein pH indicator that changes color from yellow in acidic conditions to blue in alkaline environments. Primarily functions as a diagnostic tool in advanced skincare formulations rather than delivering direct therapeutic benefits. Shows promise in smart wound care applications for monitoring skin pH changes associated with bacterial infections.

Summary

pH indicator Colorant Diagnostic agent

Science

Mechanism of Action

Functions through pH-responsive structural changes, undergoing deprotonation as environmental pH shifts from acidic to alkaline. The molecule transitions from its yellow protonated form below pH 6.0 to its blue deprotonated form above pH 7.6, serving as a real-time visual indicator of skin surface pH fluctuations.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Smart hydrogel wound dressing study (2024) demonstrated effective bacterial infection detection at 0.1-1.0% concentration without cytotoxic interference
  2. 02 SCCS safety evaluation at 0.5% concentration showed low irritancy and sensitization potential

Transparency

Dusting Analysis

Not commonly dusted

Limited use as a specialized pH indicator means dusting is unlikely; primarily appears in targeted diagnostic or color-responsive formulations

The Formula

Formulation

Solubility
Both
Optimal pH 6 – 7.6
0 7 14

Stability

Maintains stability under standard ambient conditions with color transition occurring at neutral pH. Sodium salt form demonstrates high water solubility while acid form dissolves readily in ethanol and oil-based systems.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Cationic surfactants

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.5%
Sensitization risk Low

SCCS evaluation indicates non-sensitizing and non-irritating properties at 0.5%, though comprehensive safety assessment remains incomplete due to insufficient systemic exposure and reproductive toxicity data

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

Specialized pH indicator with interesting diagnostic potential but lacking comprehensive safety data for regular skincare use.

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References

Sources