Science
Mechanism of Action
It stimulates collagen I and III biosynthesis, improves barrier function by inducing AQP3, filaggrin, and involucrin, and reduces inflammation via iNOS and NO inhibition. Additionally, it promotes adipocyte differentiation and neutralizes free radicals with its carotenoids.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 Promoted adipocyte differentiation by inhibiting hormone-sensitive lipase and promoting triglyceride accumulation.
- 02 Increased gene expression of AQP3 by 2.6-folds, FLG by 1.5-folds, and INV by 1.9-folds; induced biosynthesis of collagen I by 80% and collagen III by 40%.
- 03 Reduced inducible nitric oxide synthase (iNOS) gene expression by 50% and nitrite oxide (NO) production by 75%.
- 04 Exhibited 71% antioxidant activity in DPPH and 67% in hydroxyl radical scavenging model systems.
- 05 Did not interfere with cellular viability in cytotoxicity tests on NIH3T3 cells, HaCaT keratinocytes, and MSC cells.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
No direct optimal pH range for extract stability in cosmetic formulations was found, though algal growth typically occurs between pH 6.0-8.0.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not reviewed this ingredient. In vitro cytotoxicity tests demonstrated no interference with cellular viability up to 0.1% concentration.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Botryococcus Braunii Extract is a valuable multi-functional ingredient, clinically shown to improve hydration, boost collagen, and provide antioxidant and anti-inflammatory effects without cytotoxicity.
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References
Sources