Science
Mechanism of Action
GLA in the extract metabolizes into anti-inflammatory prostaglandins, inhibiting leukotriene synthesis to reduce skin irritation and stinging. It promotes ceramide synthesis for barrier support and delivers antioxidant protection from polyphenols, tocopherols, and Vitamin C.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Studies show 0.05%-10% concentrations effectively reduce irritation from hydroxy acids and retinoids, with 0.5%-2% being most preferred.
- 02 Topical application normalizes skin barrier function and decreases Transepidermal Water Loss (TEWL) in conditions like seborrheic and atopic dermatitis.
- 03 In vitro, a 1000 µg/mL extract increased human keratinocyte and fibroblast viability by nearly 30% without cytotoxicity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract, typically in oil form, is sensitive to oxidation. It can be formulated to mitigate irritation from other actives.
Synergies
- Hydroxy acids
- Retinoids
Conflicts
- Oxidizing agents (e.g., nitrates, oxidizing acids, chlorine bleaches)
Safety
Safety Profile
The CIR Expert Panel deems topical use safe. While internal consumption of borage products requires caution due to pyrrolizidine alkaloids (UPAs), topical application is considered possibly safe, with rare reports of non-allergic contact dermatitis.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Borago Officinalis Seed Extract is a valuable, multi-functional ingredient highly effective at soothing irritation, enhancing skin barrier, and providing antioxidant protection, especially beneficial for sensitive and compromised skin.
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