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BIS(HEXAMETHYLENE)TRIAMINE.

Avoid CAS 143-23-7 / NOT REPORTED

A high-performance alkaline monomer and structural precursor primarily utilized in the synthesis of specialized skin-conditioning agents and delivery systems. Within precision skincare, it serves as a foundational building block for creating cationic polymers and stabilizing encapsulated actives.

Monomer Chelating Agent Buffering Agent Precursor

Science

It functions as a reactive intermediate that facilitates the cross-linking of polyurea or polyamide networks, which are used to encapsulate fragile fragrances or active ingredients. When converted into amidoamine derivatives, it exhibits a high affinity for the skin's negatively charged keratin, providing significant texture-refining and softening benefits while simultaneously acting as a chelating agent to sequester destabilizing metal ions.


Research

Low confidence
Effective range 1.2–5%
Optimal

N/A

Key findings

  1. 01 Utilization in hyperbranched coatings demonstrated potent contact-killing antimicrobial efficacy against Gram-positive bacteria such as S. aureus.
  2. 02 Showed significant structural stabilization and resistance properties in high-temperature industrial fluid environments, suggesting utility in specialized protective coatings.

Transparency

Not commonly dusted
Min. effective
1%
Red flag below
0.5%

This ingredient is rarely used in its raw form in consumer-facing products; its presence is usually indicative of its use as a synthesis intermediate for other polymers. If found in a topical list at high concentrations, it would be a significant safety concern due to its inherent corrosivity.


The Formula

Solubility
Water
Optimal pH 11 – 13
0 7 14

Stability

Highly hygroscopic and reactive to atmospheric carbon dioxide; requires storage under inert gas conditions to prevent degradation.

Synergies

  • Fragrance oils (for encapsulation)
  • Cationic conditioning agents
  • Chelating systems

Conflicts

  • Strong acids
  • Isocyanates
  • Oxidizing agents
  • Peroxides
  • Halogenated organic compounds

Safety

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

In its pure state, this substance is a Category 1C corrosive with a pH of approximately 12.6, capable of causing severe chemical burns. It is intended for industrial synthesis and polymer manufacturing rather than direct application to human tissue.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Low

Our Assessment

Avoid

While essential as a chemical precursor for advanced skincare delivery systems, its raw form is highly corrosive and unsuitable for direct topical application.


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References